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BD Horizon™ BV711 Rat Anti-CD11b
BD Horizon™ BV711 Rat Anti-CD11b
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BD Horizon™ BV711 Rat Anti-CD11b

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品牌： BD Pharmingen
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    反应种属：
    Mouse (QC Testing), Human (Tested in Development)
    Mouse (QC Testing), Human (Tested in Development)
    来源宿主：
    Rat DA, also known as DA/HA IgG2b, κ
    Rat DA, also known as DA/HA IgG2b, κ
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    产品介绍
    产品信息
    耦联标记
    BV711
    抗原名称
    CD11b (Integrin aM)
    宿主
    Rat DA, also known as DA/HA IgG2b, κ
    免疫原
    Mouse Splenic Cells
    简单描述
    The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi.  Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes.  Mac-1 expression is rapidly upregulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface.  The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis.  Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
    商品描述
    M1/70 The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi.  Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes.  Mac-1 expression is rapidly upregulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface.  The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis.  Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
    同种型
    Rat DA, also known as DA/HA IgG2b, κ
    克隆号
    克隆 M1/70 (RUO)
    浓度
    0.2 mg/ml
    产品详情
    BV711
    The BD Horizon Brilliant Violet™ 711 (BV711) Dye is part of the BD Horizon Brilliant Violet™ family of dyes. This tandem fluorochrome is comprised of a BV421 donor with an excitation maximum (Ex Max) of 407-nm and an acceptor dye with an emission maximum (Em Max) at 713-nm. BV711, driven by BD innovation, is designed to be excited by the violet laser (405-nm) and detected using an optical filter centered near 710-nm (e.g., a 712/20-nm bandpass filter). The acceptor dye can be excited by the Red (628–640-nm) laser resulting in cross-laser excitation and fluorescence spillover. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
    BV711
    Violet 405 nm
    407 nm
    713 nm
    应用
    实验应用
    Flow cytometry (Routinely Tested)
    反应种属
    Mouse (QC Testing), Human (Tested in Development)
    目标/特异性
    CD11b (Integrin αM)
    背景
    别名
    Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
    制备和贮存
    存储溶液
    Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
    保存方式
    Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
    数据库链接
    Entrez-Gene ID
    16409

    参考图片

    Multiparameter flow cytometric analysis of CD11b expression on mouse bone-marrow cells. BALB/c mouse bone-marrow cells were stained with either BD Horizon™ BV711 Rat IgG2b, κ Isotype Control (Cat. No. 563045; dashed line histograms) or BD Horizon™ BV711 Rat Anti-CD11b antibody (Cat. No. 563168; solid line histogram). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of lymphoid (ie, low-to-moderate side light-scatter-gated events, Left Panel) and myeloid cells (ie, moderate-to-high side light-scatter-gated events, Right Panel). Flow cytometric analysis  was performed using a BD™ LSR II Flow Cytometer System.

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    货号：
    563168
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    供应商现货
    50ug
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