ITGAM/CD11b (C-Term) Rabbit Monoclonal Antibody (Clone RM290)

Rabbit

Peptide from the C-terminal region of human CD11b

CD11b, also known as integrin αM (ITGAM), is a protein subunit of the heterodimeric leukocyte integrin αMβ2, the major integrin expressed in phagocytes with roles in host defense.1 It is composed of an ectodomain containing a β-propeller domain followed by a thigh domain and calf-1 and calf-2 domains, a transmembrane segment, and a cytoplasmic tail.1,2 CD11b is expressed as a component of αMβ2 on the surface of leukocytes, including macrophages, dendritic cells, monocytes, neutrophils, natural killer cells, and granulocytes, that binds to ICAM and VCAM to facilitate macrophage extravasation, as well as complement C3-opsonized pathogens and immune complexes to mediate their internalization and phagocytosis.1 Mutations in ITGAM are associated with susceptibility to systemic lupus erythematosus (SLE).3 Cayman’s ITGAM/CD11b (C-Term) Rabbit Monoclonal Antibody (Clone RM290) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.

For immunochemical detection of CD11b

IgG

RM290

Antibodies/Primary Antibodies/Monoclonal Antibodies

Immunohistochemistry,Western Blot

(+) Human

(+) CD11b

Synonyms:Cell Surface Glycoprotein MAC-1 Subunit α Complement Component 3 Receptor 3 Subunit CR3A Integrin subunit αM ITGAM MAC-1

≥ 1 year