CD11c (N418) Hamster mAb (PerCP-Cy5.5 Conjugate)

CD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins (1). CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production (2, 3). CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia (4-7).The N418 antibody is widely used as a marker for CD11c expression on the cell types mentioned above (8,9). 1.Uotila, L.M. et al. (2013) J Biol Chem 288, 33494-9. 2.Kohrgruber, N. et al. (1999) J Immunol 163, 3250-9. 3.Siegal, F.P. et al. (1999) Science 284, 1835-7. 4.Racine, R. et al. (2008) J Immunol 181, 1375-85. 5.Werfel, T. et al. (1991) J Immunol 147, 2423-7. 6.Cabañas, C. et al. (1988) Hybridoma 7, 167-76. 7.Kristensen, J.S. et al. (1987) Blood 70, 1063-8. 8.Finkelman, F.D. et al. (1996) J Immunol 157, 1406-14. 9.Sadhu, C. et al. (2007) J Leukoc Biol 81, 1395-403.