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hCD11c MAb (ICRF 3.9 (500 ug)
hCD11c MAb (ICRF 3.9 (500 ug)

hCD11c MAb (ICRF 3.9 (500 ug)

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品牌： R&D Systems
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    来源宿主：
    Mouse IgG1
    Mouse IgG1
    实验应用：
    Flow Cytometry(2.5 µg/106 cells)
    Flow Cytometry(2.5 µg/106 cells)
    产品介绍
    产品信息
    耦联标记
    Unconjugated
    纯化方式
    Protein A or G purified from hybridoma culture supernatant
    抗原名称
    95 alpha chain， 95， 95, alpha subunit， CD11 antigen-like family member C， CD11c antigen， CD11c， CD11
    宿主
    Mouse IgG1
    免疫原
    Rheumatoid synovial fluid cells and human monocyte-derived fibronectin
    克隆号
    ICRF 3.9

    Human CD11c Antibody Summary

    Species Reactivity
    Human
    Specificity
    Detects human CD11c.
    Source
    Monoclonal Mouse IgG1 Clone # ICRF 3.9
    Purification
    Protein A or G purified from hybridoma culture supernatant
    Immunogen
    Rheumatoid synovial fluid cells and human monocyte-derived fibronectin
    Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

    Applications

    Recommended Concentration
    Sample
    Flow Cytometry
    2.5 µg/106 cells
    Human whole blood monocytes
    Immunoprecipitation
    Hogg, N. et al. (1986) Eur. J. Immunol. 16:240.
     
    CyTOF-ready
    Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
     

    Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

    组成成分
    IGG-免疫球蛋白G型抗体
    应用
    实验应用
    Flow Cytometry(2.5 µg/106 cells)
    背景
    别名
    95 alpha chain,95,95, alpha subunit,CD11 antigen-like family member C,CD11c antigen,CD11c,CD11Cleu M5, alpha subunit,Integrin alpha X,integrin alpha-X,integrin, alpha X (antigen CD11C (p150), alpha polypeptide),integrin, alpha X (complement component 3 receptor 4 subunit),ITGAX,Leu M5,Leukocyte adhesion glycoprotein p150,Leukocyte adhesion receptor p150,leukocyte surface antigen p150,myeloid membrane antigen, alpha subunit,p150 95 integrin alpha chain,p150,95 alpha,SLEB6
    背景

    Background: CD11c

    CD11c, also known as Integrin alpha X, is an approximately 150 kDa type I transmembrane glycoprotein that heterodimerizes with Integrin beta 2, also known as CD18. The CD11c/CD18 complex, also called CR4 (complement receptor type 4) is expressed on macrophages, dendritic cells and hairy cell leukemias, with lower amounts on other myeloid cells and activated B, NK and some cytotoxic T cells. It binds fibrinogen and has been reported to be a receptor for complement component iC3b (1‑3). The human CD11c extracellular domain (amino acids 20-1107) shares 70 - 76% amino acid sequence identity with mouse, rat and canine CD11c.

    References
    1. Hogg, N. et al. (1986) Eur. J. Immunol. 16(3):240.
    2. Knapp, W.B. et al. eds. (1989) Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.
    3. Stacker, S.A. and T.A. Springer, J. Immunol. (1991) 146(2):648.
    Entrez Gene IDs
    3687 (Human); 16411 (Mouse); 64350 (Rat)
    Alternate Names
    95 alpha chain; 95; 95, alpha subunit; CD11 antigen-like family member C; CD11c antigen; CD11c; CD11Cleu M5, alpha subunit; Integrin alpha X; integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); ITGAX; Leu M5; Leukocyte adhesion glycoprotein p150; Leukocyte adhesion receptor p150; leukocyte surface antigen p150; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain; p150,95 alpha; SLEB6
    研究领域
    制备和贮存
    溶解方法
    Reconstitute at 0.5 mg/mL in sterile PBS.
    保存方式

    Preparation and Storage

    Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
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    Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
    Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
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    货号：
    MAB1777
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    25ug
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