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Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb
品牌： CST
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对比
咨询分子量：
125
反应种属：
Human,Mouse,
产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
Jak2
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007 of human Jak2.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
同种型
Rabbit IgG
分子量
125
内毒素水平
大鼠, 猴, 牛
研究领域
免疫学和肿瘤学,神经科学,
应用
反应种属
Human,Mouse,
预测反应种属
Rat,Monkey,Bovine,
目标/特异性
Specificity/Sensitivity
Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb detects endogenous levels of Jak2 when phosphorylated at Tyr1007. This antibody can also detect double phosphorylation at Tyr1007 and Tyr1008. Cross-reactivity may be observed with phosphorylated Jak3 and Tyk2.
Species Reactivity:
Human, Mouse
敏感性
Endogenous
背景
背景
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.
1.Leonard, W.J. and O'Shea, J.J. (1998) Annu Rev Immunol 16, 293-322.
2.Darnell, J.E. (1997) Science 277, 1630-5.
3.VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93.
4.Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92.
5.Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.
研究领域
免疫学和肿瘤学,神经科学,
翻译后修饰
phosphate
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
3717
UniProt ID
O60674
参考图片
Western blot analysis of extracts from UT-7 cells, untreated or treated with erythropoietin (EPO; 3 units/ml; 5 min) and from untreated HEL cells, using Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb (upper) or total Jak2 (D2E12) Rabbit mAb #3230 (lower). HEL cells contain a V617F activating mutation in Jak2.
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