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JI051
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产品介绍
产品介绍
产品信息
商品描述
JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene HesAnti-cancer activity.
分子量
364.44
纯度
98%
可溶性
DMSO : 125 mg/mL (342.99 mM; Need ultrasonic)
In vitro(体外研究)
JI051 causes G2/M cell-cycle arrest.JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.Cell Proliferation AssayCell Line:HEK293 cellsConcentration:0.1-10 µMIncubation Time:24 hoursResult:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.
背景
分子式
C22H24N2O3
CAS号
2234281-75-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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