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产品介绍
产品介绍
产品信息
抗原名称
NF-κB
商品描述
JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.
分子量
240.34
纯度
>98%
可溶性
DMSO : 45 mg/mL (187.2 mM)
Ethanol ：16 mg/mL (66.6 mM)
Ethanol ：16 mg/mL (66.6 mM)
外观
Off-white to gray-pink powder
In vitro(体外研究)
JSH-23 inhibits LPS-induced nuclear translocation of NF-κB p65 without affecting IκBα degradation. JSH-23 inhibits LPS-induced apoptotic chromatin condensation, while does not show significant cytotoxic effects on the RAW 264.7 cells at JSH-23 also decreases NO production and neuronal migration in LPS activated cultures primary cultures from developing mouse cerebellum. Moreover, JSH-23 augments cisplatin cytotoxicity in ovarian cancer cells with CI values ranging from 0.35 to 0.85.
In vivo(体内研究)
JSH-23 (3 mg/kg) significantly reverses the nerve conduction and nerve blood flow deficits by decreasing neuroinflammation and improving antioxidant defence in diabetic rats.
背景
分子式
C16H20N2
CAS号
749886-87-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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