K-Ras (3B10-2F2)

mouse

K-Ras抗体(3B10-2F2)是小鼠单克隆IgG1 (kappa轻链)，规格为100 µg/ml 免疫human来源全长重组K-Ras 推荐用于 human 来源的K-Ras WB, IP, IF 和 ELISA检测 关于如何获取K-Ras (3B10-2F2): sc-517599的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。 m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 K-Ras Antibody (3B10-2F2) for WB 的首选应用二抗。这些试剂现在以套装形式提供K-Ras Antibody (3B10-2F2)。 (见下方订购信息). The mammalian Ras (also designated v-Ha-Ras, Harvey rat sarcoma viral oncogene homolog, HRAS1, K-Ras, N-Ras, RASH1 or c-bas/has) gene family consists of the Harvey and Kirsten Ras genes (c-H-Ras1 and c-K-Ras2), an inactive pseudogene of each (c-H-Ras2 and c-K-Ras1) and the N-Ras gene. The three Ras oncogenes, H-Ras, K-Ras and N-Ras, encode proteins with GTP/GDP binding and GTPase activity. Ras proteins alternate between an inactive form bound to GDP and an active form bound to GTP, activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Ras nomenclature originates from the characterization of human DNA sequences homologous to cloned DNA fragments containing oncogenic sequences of a type C mammalian retrovirus, the Harvey strain of murine sarcoma virus (HaMSV), derived from the rat. Under normal conditions, Ras family members influence cell growth and differentiation events in a subcellular membrane compartmentalization-based signaling system. Oncogenic Ras can deregulate processes that control both cell proliferation and apoptosis. The Ras superfamily of GTP hydrolysis-coupled signal transduction relay proteins can be subclassified into Ras, Rho, Rab and ARF families.

HumanKRAS

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