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产品介绍
产品介绍
产品信息
商品描述
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.
分子量
467.48
纯度
≥97%
可溶性
Soluble in DMSO (up to 1mg/mL)
外观
A crystalline solid
背景
别名
SF 2370
分子式
C27H21N3O5
CAS号
99533-80-9
制备和贮存
保存方式
Store at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
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