Ki-67 (D3B5) Rabbit mAb (Alexa Fluor ® 555 Conjugate)

Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival (3). Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases (4). 1.Gerdes, J. et al. (1983) Int J Cancer 31, 13-20. 2.Weigel, M.T. and Dowsett, M. (2010) Endocr Relat Cancer 17, R245-62. 3.Jones, R.L. et al. (2009) Breast Cancer Res Treat 116, 53-68. 4.Yerushalmi, R. et al. (2010) Lancet Oncol 11, 174-83.