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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Ki-67
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Ki-67 protein.
宿主
Mouse
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:800 - 1:3200 |
| Immunofluorescence (Immunocytochemistry) | 1:1600 - 1:6400 |
| Flow Cytometry (Fixed/Permeabilized) | 1:100 - 1:400 |
同种型
Mouse IgG1
研究领域
癌症,细胞生物学,
应用
反应种属
Human
目标/特异性
Specificity/Sensitivity
Ki-67 (8D5) Mouse mAb recognizes endogenous levels of total Ki-67 protein.
Species Reactivity:
Human, Monkey
敏感性
Endogenous
背景
背景
Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival (3). Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases (4).
1.Gerdes, J. et al. (1983) Int J Cancer 31, 13-20.
2.Weigel, M.T. and Dowsett, M. (2010) Endocr Relat Cancer 17, R245-62.
3.Jones, R.L. et al. (2009) Breast Cancer Res Treat 116, 53-68.
4.Yerushalmi, R. et al. (2010) Lancet Oncol 11, 174-83.
研究领域
癌症,细胞生物学,
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
For a carrier-free (BSA and azide free) version of this product see product #62548.
数据库链接
Entrez-Gene ID
4288
UniProt ID
P46013
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