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RSK1/RSK2/RSK3 (32D7) Rabbit mAb
品牌： CST
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对比
咨询分子量：
90
反应种属：
Human,Mouse,Rat,Monkey,Pig
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
RSK1RSK2RSK3
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp659 of human p90RSK.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
90
研究领域
癌症,细胞生物学,神经科学
应用
反应种属
Human,Mouse,Rat,Monkey,Pig
目标/特异性
Specificity/Sensitivity
RSK1/RSK2/RSK3 (32D7) Rabbit mAb detects endogenous levels of total RSK1/RSK2/RSK3 proteins.
Species Reactivity:
Human, Mouse, Rat, Monkey, Guinea Pig
敏感性
Endogenous
背景
背景
The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3).
1.Fisher, T.L. and Blenis, J. (1996) Mol Cell Biol 16, 1212-9.
2.Smith, J.A. et al. (1999) J Biol Chem 274, 2893-8.
3.Dalby, K.N. et al. (1998) J Biol Chem 273, 1496-505.
研究领域
癌症,细胞生物学,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
For a carrier free (BSA and azide free) version of this product see product #80908.
数据库链接
Entrez-Gene ID
6197,6196,6195
UniProt ID
P51812,Q15349,Q15418
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