全部商品分类
Phospho-RSK3 (Thr356/Ser360) Antibody
品牌： CST
用小程序，查商品更便捷
收藏
对比
咨询分子量：
90
反应种属：
Human,Mouse,Rat,Monkey,
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
RSK3
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr356/Ser360 of human RSK3. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
分子量
90
研究领域
癌症,细胞生物学,神经科学
应用
反应种属
Human,Mouse,Rat,Monkey,
目标/特异性
Specificity/Sensitivity
Phospho-RSK3 (Thr356/Ser360) Antibody detects endogenous levels of RSK3 only when phosphorylated at threonine 356 and serine 360. The antibody does not recognize RSK3 phosphorylated at other sites. It shows some cross-reactivity with RSK1 and RSK2 when phosphorylated at the homologous sites.
Species Reactivity:
Human, Mouse, Rat, Monkey
敏感性
Endogenous
背景
背景
The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3). crazy
1.Fisher, T.L. and Blenis, J. (1996) Mol Cell Biol 16, 1212-9.
2.Smith, J.A. et al. (1999) J Biol Chem 274, 2893-8.
3.Dalby, K.N. et al. (1998) J Biol Chem 273, 1496-505.
研究领域
癌症,细胞生物学,神经科学
翻译后修饰
phosphate
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
6197,6196,6195
UniProt ID
P51812,Q15349,Q15418
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。