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产品介绍
产品介绍
产品信息
商品描述
L-168049 is a potent, selective and non-competitive antagonist of the human glucagon receptor (hGR). It binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively).
分子量
467.79
纯度
≥98%
可溶性
Soluble in DMSO (100 mM), and ethanol (100 mM).
外观
Light beige solid
IC50
Human GR: IC50 = 3.7 nM; Glucagon receptor: IC50 = 37 nM (mouse); Glucagon-stimulated cAMP synthesis in CHO cells expressing hGR: IC50 = 41 nM; Canine GR: IC50 = 60 nM; Murine GR: IC50 = 63 nM
背景
分子式
C24H20BrClN2O
CAS号
191034-25-0
沸点
542.33° C at 760 mmHg (Predicted)
MDL
MFCD08703112
PK值
pKa: 13.99 (Predicted), pKb: 5.48 (Predicted)
密度
1.37 g/cm3 (Predicted)
折射率
n20D 1.63 (Predicted)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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