L-745,870 trihydrochloride (10 mg)

49759035

Highly selective D₄ antagonist

436.21

3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

A highly potent and selective D₄ dopamine receptor antagonist; L-745,870 has K_i values of 0.51, 2300 and 960 nM for D₄, D₃ and D₂ subtypes respectively and > 1000-fold selectivity over 5-HT₂, D₁ and D₅ receptors.

≥99% (HPLC)

Soluble to 100 mM in water

Cl.Cl.Cl.ClC1=CC=C(C=C1)N1CCN(CC2=CNC3=NC=CC=C23)CC1

C₁₈H₁₉N₄Cl.3HCl

866021-03-6