L-748,337 (10 mg)

10028830

Selective β₃ antagonist

497.61

N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide

Competitive β₃-adrenoceptor antagonist that displays selectivity over β₁ and β₂ receptors (K_i values are 4.0, 204 and 390 nM for β₃-, β₂- and β₁-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC₅₀ = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 25 mM in ethanol

O[C@H](COC2=CC=CC(CNC(C)=O)=C2)CNCCC1=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C1

C₂₆H₃₁N₃O₅S

244192-94-7