LAG3 (D2G4O) Rabbit mAb

Lymphocyte activation gene 3 (LAG3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region (1). LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, Tregs, and NK cells, where it's activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells (2), LAG3 can also inhibit CD8+ T cells (3,4). LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to contribute to tumor-mediated immune suppression (4,5). Blockade of LAG3 is a promising strategy for neoplastic intervention (6). 1.Triebel, F. et al. (1990) J Exp Med 171, 1393-405. 2.Huang, C.T. et al. (2004) Immunity 21, 503-13. 3.Grosso, J.F. et al. (2007) J Clin Invest 117, 3383-92. 4.Woo, S.R. et al. (2012) Cancer Res 72, 917-27. 5.Matsuzaki, J. et al. (2010) Proc Natl Acad Sci U S A 107, 7875-80. 6.Goldberg, M.V. and Drake, C.G. (2011) Curr Top Microbiol Immunol 344, 269-78.