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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Cleaved Lamin A
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues surrounding Asp230 in human lamin A. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
45, 50
研究领域
表观遗传学,神经科学,
应用
反应种属
Human,Mouse,Rat,
目标/特异性
Specificity/Sensitivity
Cleaved Lamin A (Asp230) Antibody detects endogenous levels of the large fragment of lamin A (and lamin C isotype) resulting from cleavage at aspartic acid 230. The antibody does not recognize full length lamin A.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear dysregulation and cell death (5,6).(This product is sold under license from Promega Corp., U.S. Patent No. 6,350,452.)
1.Gruenbaum, Y. et al. (2000) J Struct Biol 129, 313-23.
2.Yabuki, M. et al. (1999) Physiol Chem Phys Med NMR 31, 77-84.
3.Goldberg, M. et al. (1999) Crit Rev Eukaryot Gene Expr 9, 285-93.
4.Orth, K. et al. (1996) J Biol Chem 271, 16443-6.
5.Oberhammer, F.A. et al. (1994) J Cell Biol 126, 827-37.
6.Rao, L. et al. (1996) J Cell Biol 135, 1441-55.
研究领域
表观遗传学,神经科学,
翻译后修饰
cleaved
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
4000
UniProt ID
P02545
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