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产品介绍
产品介绍
产品信息
抗原名称
PP2A
商品描述
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
分子量
268.31
纯度
98%
可溶性
Water ：53mg/ml(197.53 mM)
外观
white solid
In vitro(体外研究)
LB-100 inhibits the cell growth with IC50 of 2.3 μM (in BxPc-3) or 1.7 μM (in Panc-1 cell). In BxPc-3, Panc-1, and SW1990 cells, LB-100 reduces the PP2A activity by 30-50%. LB-100 increases concentration of doxorubicin within cells (2.5 fold to control) and sensitizes tumor cells to the cytotoxicity of doxorubicin. LB-100 increaseds VEGF secretion, and thus enhances HIF-1α-VEGF mediated angiogenesis.
In vivo(体内研究)
In a mouse pancreatic cancer xenograft model, LB-100 (2 mg/kg, i.p.) enhances chemotherapy of doxorubicin. LB-100 causes higher density of microvessel in tumors and rapid blood flow at the surface of tumors.
背景
分子式
C13H20N2O4
CAS号
1632032-53-1；1026680-07-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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