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LC10
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产品介绍
产品介绍
产品信息
简单描述
LC10 is a lipidoid derivative of the secondary bile acid lithocholic acid (Item No. 20253) that contains two 10-carbon alkyl chains.1 It has been used in the generation of self-assembling skin-permeable lipid nanoparticles (LNPs). LC10 LNPs inhibit the proliferation of normal human epidermal keratinocytes (NHEKs) when used at a concentration of 100 nM and reduce the levels of TNF-α, IL-17, and IL-23 in human peripheral blood mononuclear cells (PBMCs) at 50, 100, and 200 nM. Topical application of LC10 LNPs (10 mg/kg) reduces psoriatic-like plaques and reverses weight loss induced by imiquimod (Item No. 14956) in a mouse model of psoriasis.WARNING This product is not for human or veterinary use.
商品描述
A lipidoid derivative of lithocholic acid
分子量
699.2
纯度
≥98%
产品类型
Biochemicals,Lipid Nanoparticles (LNPs)/Sterol Lipids,Lipids
背景
别名
Formal_Name:(3α,5β)-N-[2-(didecylamino)ethyl]-3-hydroxy-cholan-24-amide
研究领域
Immunology & Inflammation/Autoimmunity/Innate Immunity
结构式
C[C@H](CCC(NCCN(CCCCCCCCCC)CCCCCCCCCC)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C
分子式
C46H86N2O2 • HCl
CAS号
2768690-22-6
制备和贮存
保存
≥ 1 year
溶解方法
Ethanol: 100 mg/ml
保存方式
-20°C
数据库链接
UN No.
1170
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