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产品介绍
产品介绍
产品信息
商品描述
Lck Inhibitor II is a cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50 = 3 nM; [ATP] = 10 μM). Lck Inhibitor II has been reported to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 54 nM) stimulated by CD3 cross-linking and PMA.
分子量
446.51
纯度
≥97%
可溶性
Soluble in DMSO (35 mg/ml), and ethanol (20 mg/ml).
IC50
Lck : IC50 = 3 nM; IL-2 release: IC50 = 54 nM (Jurkat E6-1 T cell line)
应用
实验应用
A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine
背景
分子式
C24H26N6O3
CAS号
918870-43-6
密度
~1.37 g/cm3 (Predicted)
折射率
n20D ~1.69 (Predicted)
制备和贮存
保存方式
Store at 4° C
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