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LDH-IN-1
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产品介绍
产品介绍
产品信息
抗原名称
LDHB:27 nM (IC50), LDHA:32 nM (IC50)
商品描述
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
纯度
98%
可溶性
DMSO:50 mg/mL (87.61 mM)
In vitro(体外研究)
LDH-IN-1 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.
In vivo(体内研究)
LDH-IN-1 shows clearance values that far exceed hepatic blood flow ?in mouse species (90 mL/min/kg), with in vivo clearances of 227 mL/min/kg[1].
背景
分子式
C30H26N4O4S2
CAS号
1964515-43-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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