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hLILRB5 MAb (Cl 3952 (25 ug)
hLILRB5 MAb (Cl 3952 (25 ug)

hLILRB5 MAb (Cl 3952 (25 ug)

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品牌： R&D Systems
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    来源宿主：
    Mouse IgG2b
    Mouse IgG2b
    实验应用：
    Western Blot(1 µg/mL)
    Western Blot(1 µg/mL)
    产品介绍
    产品信息
    耦联标记
    Unconjugated
    纯化方式
    Protein A or G purified from hybridoma culture supernatant
    抗原名称
    CD85 antigen-like family member C， CD85c antigen， CD85c， Leukocyte immunoglobulin-like receptor 8， l
    宿主
    Mouse IgG2b
    免疫原
    Mouse myeloma cell line NS0-derived recombinant human LILRB5/CD85c/LIR-8 isoform 1
    Arg18-His456
    Accession # O75023
    克隆号
    395239

    Human LILRB5/CD85c/LIR-8 Antibody Summary

    Species Reactivity
    Human
    Specificity
    Detects human LILRB5/CD85c/LIR-8 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) ILT1, 2, 3, 4, 5, rhLIR-6, or rhILT11/LILRA5 is observed. In Western blots, less than 5% cross-reactivity with rhILT2, 3, 5, rhLIR-6 or rhILT11/LILRA5 is observed, and no cross-reactivity with rhILT1, 4, or 6.
    Source
    Monoclonal Mouse IgG2B Clone # 395239
    Purification
    Protein A or G purified from hybridoma culture supernatant
    Immunogen
    Mouse myeloma cell line NS0-derived recombinant human LILRB5/CD85c/LIR-8 isoform 1
    Arg18-His456
    Accession # O75023
    Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

    Applications

    Recommended Concentration
    Sample
    Western Blot
    1 µg/mL
    Recombinant Human LILRB5/CD85c/LIR-8

    Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

    组成成分
    IGG-免疫球蛋白G型抗体
    应用
    实验应用
    Western Blot(1 µg/mL)
    背景
    别名
    CD85 antigen-like family member C,CD85c antigen,CD85c,Leukocyte immunoglobulin-like receptor 8,leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains),LILRB5,LIR8,LIR-8,LIR8CD85C,LIR-8leukocyte immunoglobulin-like receptor subfamily B member 5,member 5,Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 5
    背景

    Background: LILRB5/CD85c/LIR-8

    Human LIR-8 (leukocyte immunoglobulin-like receptor 8; also CD85c and LILRB5) is a 567 amino acid (aa) member of the LIR family of receptors. It is a type I transmembrane protein that is expressed on NK cells. LIR-8 has a 435 aa extracellular domain with four C2-type Ig-like domains (aa 24‑458), and a 111 aa cytoplasmic tail that contains two ITIM motifs. Phosphorylation of Tyr in an ITIM motif recruits SHP-1, which is subsequently activated and impacts related signaling pathways. The ligand for, and function of, LIR-8 are unreported. LIR-8 has two potential splice forms. One shows a 53 aa cytoplasmic insert between Arg542 and Ala543. The second shows a deletion of 100 aa between Gly119 and Gly219 that impacts the second C2-type Ig-like domain. There is no rodent ortholog.

    Long Name
    Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 5
    Entrez Gene IDs
    10990 (Human); 102129427 (Cynomolgus Monkey)
    Alternate Names
    CD85 antigen-like family member C; CD85c antigen; CD85c; Leukocyte immunoglobulin-like receptor 8; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB5; LIR8; LIR-8; LIR8CD85C; LIR-8leukocyte immunoglobulin-like receptor subfamily B member 5; member 5
    研究领域
    制备和贮存
    溶解方法
    Reconstitute at 0.5 mg/mL in sterile PBS.
    保存方式

    Preparation and Storage

    Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
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    Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
    Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
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    货号：
    MAB3065-SP
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    询价
    25ug
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