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(R)-(+)-α-Lipoic acid
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产品介绍
产品介绍
产品信息
商品描述
R(+)-α-lipoic acid, a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate.
分子量
206.33
纯度
＞98%
可溶性
DMSO ：41 mg/mL (198.71 mM)
外观
yellow crystalline
In vitro(体外研究)
Using L6 myotubes and 3T3-L1 adipocytes as a model of muscle and fat cells in culture, R(+)-α-lipoic acid (R-LA) is shown to increase tyrosine phosphorylation of insulin receptor and IRS-1, to enhance PI 3-kinase and Akt1 activities, to elevate GLUT4 content in the plasma membranes, and to increase glucose uptake into the cells. 3T3-L1 adipocytes possess a low capacity to reduce R-α-lipoic acid and the oxidized isoforms are effective in stimulating glucose transport. R-α-lipoic acid modulates glucose transport by changing intracellular redox status. Insulin receptor is a target of R-LA action.
背景
别名
(R)-(+)-α-硫辛酸；(+)-α-Lipoic acid；α-Lipoic acid
分子式
C8H14O2S2
CAS号
1200-22-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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