LPD-12

LPD-12 is a water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 μM and [protein] ~ 22 μM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.