mAb anti-Amyloid Beta Peptide 42

Protein G affinity purified

鼠

KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminus of Aβ42

Description:Description: Mouse monoclonal antibody to C-terminus of amyloid beta peptide 42 (Aβ42). BackgroundAmyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 consitituents the intial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contibutes to the pathogenesis of Alzheimer's. One propsition is that the deposition of amyloid fibril onto the brain tissues results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

CA9 10C11

Lyophilized from a solution in 0.01M PBS, pH 7.2

Monoclonal

免疫球蛋白G型抗体

Sandwich ELISA (S-EIA), Western Blot (WB), Dot Blot (DB)

Human and other primates; mouse, rat

Beta amyloid peptide 42; Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42)