MAD1 (9B10)

MAD1

human

mouse

MAD1抗体(9B10)是小鼠单克隆IgG2b κ, 在18篇文献中引用，规格为200 µg/ml免疫human来源的MAD1全长MAD1 抗体 (9B10) 推荐用于WB, IP, IF, IHC(P), FCM 和 ELISA，检测human 来源的 MAD1MAD1 抗体 (9B10) 可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM还可偶联Alexa Fluor® 594 用于IF, IHC(P) 和 FCM还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统关于如何获取MAD1 (9B10): sc-47746的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。m-IgG2b BP-HRP 是MAD1 Antibody (9B10) for WB and IHC(P)首选应用二抗. 这些试剂现在以套装形式提供MAD1 Antibody (9B10) (见下方订购信息). 查看产品引用文献(18) Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD1 and MAD2 (for mitotic arrest-deficient 1 and 2) are components of the mitotic spindle checkpoint. Incorrect spindle assembly in normal cells leads to mitotic arrest. MAD1 prevents the onset of anaphase until all chromosomes are aligned correctly at the metaphase plate and is crucial for anchoring MAD2L1 to the nuclear periphery. It also plays an important role in septum positioning. MAD1 can form a homo-dimer, but may also form a heterodimer with MAD2 to form the tetrameric MAD1L1-MAD2L1 core complex. MAD1 localizes primarily to the nucleus, but during mitosis, it moves from a nuclear distribution to the centrosome, to the spindle midzone and then on to the midbody. MAD1 activity is induced by BUB1 and the protein is hyperphosphorylated after mitotic spindle damage and/or in late S through M phase. Defects in the gene encoding for MAD1, MAD1L1, play a major role in the development and progression of various cancer types.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USALI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

MAD1抗体(9B10)是小鼠单克隆IgG2b κ, 在21篇文献中引用，规格为200 µg/ml 针对全长MAD1，human起源 MAD1 抗体 (9B10) 推荐用于WB, IP, IF, IHC(P), FCM 和 ELISA，检测human 来源的 MAD1 MAD1 抗体 (9B10) 可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM 还可偶联Alexa Fluor® 594 用于IF, IHC(P) 和 FCM 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统 2b BP-HRP">m-IgG2b BP-HRP是MAD1 Antibody (9B10) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与MAD1 Antibody (9B10) 打包提供（请参阅下面的订购信息）。

IgG2b kappa light chain

9B10

单克隆抗体

HumanMAD1L1