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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu452 of human MAP4K3 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
101
应用
目标/特异性
Specificity/Sensitivity
MAP4K3 (D1L4G) Rabbit mAb recognizes endogenous levels of total MAP4K3 protein.
Species Reactivity:
Human, Monkey
敏感性
Endogenous
背景
背景
The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by growth factors and nutrients including amino acids (1,2). MAP4K3 is a mediator between nutrient signal and mTORC1 (1). Research studies suggest that amino acid sufficiency leads to the phosphorylation of Ser170 on MAP4K3, which activates mTORC1 (3).
1.Findlay, G.M. et al. (2007) Biochem J 403, 13-20.
2.Sancak, Y. et al. (2008) Science 320, 1496-501.
3.Yan, L. et al. (2010) Mol Cell 37, 633-42.
研究领域
癌症,细胞生物学,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
8491
UniProt ID
Q8IVH8
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