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Maytansinol
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产品介绍
产品介绍
产品信息
抗原名称
Maytansinoids
商品描述
Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
分子量
565.06
纯度
98%
可溶性
DMSO : ≥ 35 mg/mL (61.94 mM)
外观
White to yellow solid
In vitro(体外研究)
Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.
背景
别名
美登醇；Ansamitocin P-0
分子式
C28H37ClN2O8
CAS号
57103-68-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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