MBL (E2F7B) Rabbit mAb

Mannose-binding lectin (MBL) is a member of the collectin family of proteins and plays a key role in innate immunity via activation of the lectin complement pathway (1). MBL is produced in the liver and circulates in the serum in complexes with MBL-associated serine proteases (MASPS) (1,2). MBL acts as a pattern recognition receptor and binds carbohydrates on the surface of various microorganisms as well as on dying host cells (3,4). In humans, only one MBL protein form is found in the serum, but in rodents, two MBL forms have been characterized, MBL-A and MBL-C (5). Polymorphisms in the MBL gene, MBL-2, are associated with predisposition to myocardial infarction, pathogenesis of pulmonary tuberculosis (PTB), and three single point mutations in exon 1 are responsible for the most common human immunodeficiencies leading to increased susceptibility to infectious disease (6-8). 1.Petersen, S.V. et al. (2001) Mol Immunol 38, 133-49. 2.Wallis, R. (2007) Immunobiology 212, 289-99. 3.Köhl, J. (2006) Immunol Res 34, 157-76. 4.Holers, V.M. (2014) Annu Rev Immunol 32, 433-59. 5.Hansen, S. and Holmskov, U. (1998) Immunobiology 199, 165-89. 6.Vengen, I.T. et al. (2012) PLoS One 7, e42113. 7.Areeshi, M.Y. et al. (2016) Sci Rep 6, 35728. 8.Turner, M.W. (2003) Mol Immunol 40, 423-9.