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产品介绍
产品介绍
产品信息
抗原名称
SRC
商品描述
MCB-613 is a potent steroid receptor coactivator (<b>SRC</b>) stimulator.
分子量
304.39
纯度
＞98%
可溶性
体外:
DMSO 60mg/mLwarming(197.11mM)
Ethanol 60mg/mLwarming(197.11mM)
Water <1mg/mL
4%DMSO+30%PEG300+ddH2O 2mg/mL
DMSO 60mg/mLwarming(197.11mM)
Ethanol 60mg/mLwarming(197.11mM)
Water <1mg/mL
4%DMSO+30%PEG300+ddH2O 2mg/mL
In vitro(体外研究)
MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS).
In vivo(体内研究)
In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less.
背景
分子式
C20H20N2O
CAS号
1162656-22-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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