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MCC-950 sodium
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产品介绍
产品介绍
产品信息
抗原名称
NLRP3
商品描述
MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
分子量
426.46
纯度
>98%
可溶性
DMSO ：42.7 mg/mL (100 mM)
Water ：42.7 mg/mL (100 mM)
Water ：42.7 mg/mL (100 mM)
外观
white to beige Powder
In vitro(体外研究)
MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.
In vivo(体内研究)
MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.
背景
分子式
C20H23N2NaO5S
CAS号
256373-96-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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