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产品介绍
产品介绍
产品信息
抗原名称
11β-HSD1
商品描述
An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
分子量
226.27
纯度
98%
可溶性
water : ≥ 38 mg/mL (167.94 mM)
外观
White solid
In vitro(体外研究)
Metyrapone is a well known inhibitor of 11β-hydroxylase, a key enzyme involved in the final step of cortisol biosynthesis. At higher concentrations, it also inhibits other steroidogenic enzymes such as cholesterol side chain cleavage enzyme. It is specific for 11β-HSD1 while it has little effect on 11β-HSD2 activity.
In vivo(体内研究)
The administration of metyrapone to man, and animals such as the dog and sheep thus leads to a decrease in circulating levels of cortisol.
背景
别名
美替拉酮；甲吡酮；Su-4885
分子式
C14H14N2O
CAS号
54-36-4
制备和贮存
保存方式
Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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