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MG-115
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产品介绍
产品介绍
产品信息
商品描述
MG-115 is a potent, reversible proteasome inhibitor. MG-115 specifically inhibits the chymotrypsin-like activity of the proteasome. MG-115 is an inhibitor of 20S Proteasome and 26S Proteasome. It has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.
分子量
461.59
纯度
98%
可溶性
Soluble in DMSO (50 mg/ml), and methanol (1 mg/ml).
外观
white Ppowder
Ki 数据
20S proteasome: Ki= 21 nM; 26S proteasome: Ki= 35 nM
背景
分子式
C25H39N3O5
CAS号
133407-86-0
沸点
678.79° C at 760 mmHg (Predicted)
密度
1.08 g/cm3 (Predicted)
折射率
n20D 1.51 (Predicted)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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