MGMT (C-5)

mouse

MGMT抗体(C-5)是小鼠单克隆IgG1 κ, 在4篇文献中引用，规格为200 µg/ml免疫human物种的代表全长MGMT的氨基酸1-207推荐用于 human 来源的MGMT WB, IP, IF, IHC(P) 和 ELISA检测看 MGMT (E-1): sc-166528，可查看有标记的 MGMT 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790m-IgG Fc BP-HRP and m-IgG1 BP-HRP 是 MGMT Antibody (C-5) for WB and IHC(P)首选应用二抗。这些试剂现在以套装形式提供MGMT Antibody (C-5) (见下方订购信息). 查看产品引用文献(4) MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

IGG-免疫球蛋白G型抗体

MouseMgmt

human

4255