MHC class II (IBL-5/22)

rat

MHC class II 抗体 IBL-5/22 是大鼠单克隆 IgG1, 在11篇文献中引用，提供 100 µg/mlraised against spleen cells of mouse origin推荐用于 mouse 来源的MHC class II WB, IP, IF 和 FCM检测关于如何获取MHC class II (IBL-5/22): sc-59322的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。目前，我们还没有完成MHC class II 抗体 (IBL-5/22)的首选二抗检测试剂的鉴定。这项工作正在进行中。 查看产品引用文献(11) Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

主要组织相容性复合体ⅱ类抗体

WB, IP, IF, FCM

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