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产品介绍
产品介绍
产品信息
抗原名称
Sterol-O-Acyl Transferase 1
商品描述
Mitotane (Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease.
分子量
320.04
纯度
>98%
可溶性
Ethanol ：60 mg/mL (187.5 mM)
DMSO ：60 mg/mL (187.5 mM)
DMSO ：60 mg/mL (187.5 mM)
外观
白色结晶固体
In vitro(体外研究)
Mitotane inhibits both TSH expression and secretion, blocks TSH response to TRH, and reduces cell viability, inducing apoptosis at concentrations in the therapeutic window in the mouse TalphaT1 cell line. Mitotane does not interfere with thyroid hormone laboratory tests but directly reduces both secretory activity and cell viability on pituitary TSH-secreting mouse cells. Mitotane induces adrenal cortex necrosis, mitochondrial membrane impairment, and irreversible binding to CYP proteins. Mitotane (10-40μM) inhibits basal and cAMP-induced cortisol secretion but does not cause cell death. Mitotane exhibits an inhibitory effect on the basal expression of StAR and P450scc protein. Mitotane (40 μM) significantly diminishes StAR, CYP11A1 and CYP21 mRNA expression. Mitotane (40μM) almost completely neutralizes this positive effect and returned 8-Br-cAMP-induced StAR, CYP11A1, CYP17 and CYP21 mRNA to control levels. Mitotane and gemcitabine combinations show antagonistic effects and interfered with the gemcitabine-mediated inhibition of the S phase of the cell cycle in H295R cells.
In vivo(体内研究)
Mitotane (60 mg/kg) significantly decreases adrenal mitochondrial and microsomal "P-450" and microsomal protein contnet 34%, 55%, and 35% respectively in rats, within 3 hours.
背景
别名
米托坦；2,4′-DDD；o,p‘-DDD
分子式
C14H10Cl4
CAS号
53-19-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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