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ML130 (Nodinitib-1)
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产品介绍
产品介绍
产品信息
抗原名称
NOD1; NOD2; TNF-α;
商品描述
ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.
分子量
287.34
纯度
＞98%
可溶性
DMSO : 28.7 mg/mL (100 mM)
Ethanol : 2.9 mg/mL (10 mM)
Ethanol : 2.9 mg/mL (10 mM)
外观
white to beige powder
In vitro(体外研究)
ML130 has shown selective inhibition of NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity and is selected as a probe candidate molecule. ML130 is also confirmed in secondary assays by selectively inhibiting NOD1-dependent IL-8 secretion and also selectively inhibiting the NOD1-dependent pathway to NF-κB activation. In another research, ML130 is proved to cause conformational changes of NOD1 in vitro and alter NOD1 subcellular targeting in cells, providing chemical probes for interrogating mechanisms regulating NOD1 activity and tools for exploring the roles of NOD1 in various infectious and inflammatory diseases.
背景
别名
ML130; CID-1088438
分子式
C14H13N3O2S
CAS号
799264-47-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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