MOG (D5B4C) Rabbit mAb

Myelin-oligodendrocyte glycoprotein (MOG) is a type I membrane bound glycoprotein of the immunoglobulin superfamily that is enriched in the outer lamella of the myelin sheath (1). The myelin sheath is a multi-layered membrane structure composed of oligodendrocytes that increases the conduction velocity of axonal impulses. The specific function of MOG is unknown, but MOG’s structure and expression during later stages of myelinogenesis suggests a role in myelin sheath maturation and maintenance (2). MOG may be an autoimmune target in central nervous system inflammatory diseases such as multiple sclerosis (MS) (3). Induction of MOG autoimmunity is also used as an experimental model for MS as injections of MOG peptide or recombinant protein in rodent models causes severe neurological disease that recapitulates several clinical features of MS (4). 1.Johns, T.G. and Bernard, C.C. (1999) J Neurochem 72, 1-9. 2.Clements, C.S. et al. (2003) Proc Natl Acad Sci U S A 100, 11059-64. 3.Androutsou, M.E. et al. (2018) Med Chem 14, 120-8. 4.Linington, C. et al. (1993) Eur J Immunol 23, 1364-72.