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咨询Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Huntingtin（Htt）是由Htt基因编码的蛋白质，也称为IT15基因。突变的HTT是亨廷顿氏病（HD）的病因，已经对此作用以及其参与长期记忆储存进行了研究。它的结构是可变的，因为该基因的许多多态性可导致蛋白质中存在不同数量的谷氨酰胺残基。在其野生型（正常形式）中，含有6-35个谷氨酰胺残基。然而，在受亨廷顿病（一种常染色体显性遗传病）影响的个体中，它含有36个以上的谷氨酰胺残基（最高报告重复长度约为250）。它常用的名字来源于这种疾病。
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
参考图片
Blocking buffer: 5% NFDM/TBST Primary antibody dilution: 1:1000 Primary antibody incubation condition: 2 hours at room temperature Secondary antibody: Goat Anti-Mouse IgG H&L (HRP) Lysate:1: SH-SY5Y, 2: JurKat, 3: Mouse brain, 4: Rat brain Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 348 kDa Observed MW: 348 kDa
Cell line: SH-SY5Y Fixative: 100% Ice-cold methanol Permeabilization: 0.1% TritonX-100 Primary antibody dilution: 1:50 Primary incubation condition: 4°C overnight Secondary antibody: Goat Anti-Mouse IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for abs154818.