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Mouse DPP7 / DPPII / DPP2 Protein (His Tag)
Mouse DPP7 / DPPII / DPP2 Protein (His Tag)
品牌： Sino Biological
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对比
咨询分子量：
The recombinant mouse DPP7 consists of 484 amino acids and predicts a molecular mass of 53.7 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmDPP7 is approximately 65 KDa as a result of glycosylation.
纯度：
> 92 % as determined by SDS-PAGE
产品介绍
产品介绍
产品信息
抗原名称
dipeptidyl-peptidase 7
N端序列分析
Asp 34
分子量
The recombinant mouse DPP7 consists of 484 amino acids and predicts a molecular mass of 53.7 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmDPP7 is approximately 65 KDa as a result of glycosylation.
生物活性
Measured by its ability to cleave the fluorogenic peptide substrate, Lys-Pro-AMC(KP-AMC).
The specific activity is > 20,000 pmoles/min/μg.
纯度
> 92 % as determined by SDS-PAGE
内毒素水平
< 1.0 EU per μg of the protein as determined by the LAL method
形式
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
表达系统
HEK293
研究领域
其他
应用
反应种属
Mouse
背景
别名
Dpp2 Protein, Mouse; Dpp7 Protein, Mouse; DPPII Protein, Mouse; QPP Protein, Mouse
背景
DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.
Full Name
dipeptidyl-peptidase 7
Research Areas
Serine Proteases and Regulators
References
Chiravuri M, et al. (1999) A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J Immunol. 163(6):3092-9.Fukasawa KM, et al. (2001) Cloning and functional expression of rat kidney dipeptidyl peptidase II. Biochem J. 353(Pt 2):283-90.Fornas E, et al. (1992) Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells. Histol Histopathol. 7(2):163-8.
研究领域
Serine Proteases and Regulators
制备和贮存
保存方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
数据库链接
Accession
Q9ET221
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