Mouse Monoclonal HLA DR/DP Antibody (Bra-14) - IHC-Prediluted

Protein A or G purified

Mouse

Human REH cells

The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.

IgG3 Kappa

Monoclonal

Protein A or G purified

0.05% Sodium Azide

Monoclonal

HLA-DRA

Immunohistochemistry Immunohistochemistry-Paraffin

HuSpecies Glossary

Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36kDa) and a chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.