Anti-MRP3 antibody [ABCC3/2971]

Purified from Bioreactor concentrate

ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed : 10359813, PubMed : 11581266, PubMed : 15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed : 11581266, PubMed : 15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed : 10359813, PubMed : 11581266).

Mouse

Recombinant fragment within Human MRP3 aa 800-1000. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.Database link: O15438-1

小鼠单克隆抗体[ABCC3/2971] to MRP3

IgG1

ABCC3/2971

单克隆

kappa

Protein A/G purified

0.2 mg/mL 本产品的浓度可能与批次相关

Liquid

癌症

Protein Array, IHC-P

Human

CMOAT2, MLP2, MRP3, ABCC3, ATP-binding cassette sub-family C member 3, Canalicular multispecific organic anion transporter 2, Multi-specific organic anion transporter D, Multidrug resistance-associated protein 3, MOAT-D

pH: 7.2Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA

O15438-1&&O15438&&O15438