MRP6 (M6II-31)

鼠

MRP6 抗体 M6II-31 是大鼠单克隆 IgG2a, 在5篇文献中引用，提供 500 µl supernatant raised against a bacterial fusion protein mapping to amino acids 764-964 of MRP6 of human origin 推荐用于 human 来源的MRP6 WB, IF 和 IHC(P)检测; 不会与 MDR1, MRP1, MRP2 or MRP3, MRP4 and MRP5产生交联反应 目前，我们还没有完成MRP6 抗体 (M6II-31)的首选二抗检测试剂的鉴定。这项工作正在进行中。 The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues, yet at much lower levels of expression.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

单抗

干冰

HumanABCC6

WB, IF, IHC(P)

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