全部商品分类
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
抗原名称
SDMA:3 nM(HCT116 MTAP-del cells), SDMA:544 nM(HCT116 MTAP-WT cells), cell proliferation:11 nM(HCT116 MTAP-del cells), cell proliferation:861 nM(HCT116 MTAP-WT cells)
商品描述
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
分子量
424.43
纯度
98%
可溶性
DMSO:35 mg/ml(82.46 mM)
In vitro(体外研究)
MRTX-9768, a potent inhibitor of SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM).
In vivo(体内研究)
In xenograft studies, oral administration of MRTX-9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow[1].
背景
分子式
C24H17FN6O
CAS号
2629314-68-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。