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产品介绍
产品介绍
产品信息
抗原名称
BRD4-BD1:77 nM (Ki), BRD3-BD2:200 nM (Ki), BRD4-BD2:718 nM (Ki), BRD3-BD1:110 nM (Ki), BRD2-BD2:240 nM (Ki), BRD2-BD1:83 nM (Ki)
商品描述
MS402 is a novel BD1-selective BET BrD inhibitor.
分子量
370.83
纯度
98%
可溶性
DMSO:22.5 mg/mL (60.67 mM)
In vitro(体外研究)
MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation.?Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment.
背景
分子式
C20H19ClN2O3
CAS号
1672684-68-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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