MTAP (A8N9F) Rabbit mAb

MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine (1,2). MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors, including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma, and breast carcinoma. MTAP is usually codeleted with p16 (cdkN2a/ARF) (3-5). MTAP overexpression in breast cancer cells inhibits their ability to form colonies in soft agar, thereby implicating its function as a tumor suppressor (6). 1.Backlund, P.S. and Smith, R.A. (1981) J Biol Chem 256, 1533-5. 2.Backlund, P.S. et al. (1982) J Biol Chem 257, 4196-202. 3.Dreyling, M.H. et al. (1998) Genes Chromosomes Cancer 22, 72-8. 4.Zhang, H. et al. (1996) Cancer Genet Cytogenet 86, 22-8. 5.Illei, P.B. et al. (2003) Clin Cancer Res 9, 2108-13. 6.Christopher, S.A. et al. (2002) Cancer Res 62, 6639-44.