

产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
MTAP

来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the N terminus of human MTAP. Antibodies were purified by protein A and peptide affinity chromatography.

宿主
Rabbit

商品描述
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |

分子量
29

研究领域
癌症,代谢,神经科学

应用
反应种属
Human,Mouse,Rat,Monkey,

目标/特异性
Specificity/Sensitivity
MTAP Antibody detects endogenous levels of total MTAP protein.
Species Reactivity:
Human, Mouse, Rat, Monkey

敏感性
Endogenous

背景
背景
MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine (1,2). MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors, including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma, and breast carcinoma. MTAP is usually codeleted with p16 (cdkN2a/ARF) (3-5). MTAP overexpression in breast cancer cells inhibits their ability to form colonies in soft agar, thereby implicating its function as a tumor suppressor (6).
1.Backlund, P.S. and Smith, R.A. (1981) J Biol Chem 256, 1533-5.
2.Backlund, P.S. et al. (1982) J Biol Chem 257, 4196-202.
3.Dreyling, M.H. et al. (1998) Genes Chromosomes Cancer 22, 72-8.
4.Zhang, H. et al. (1996) Cancer Genet Cytogenet 86, 22-8.
5.Illei, P.B. et al. (2003) Clin Cancer Res 9, 2108-13.
6.Christopher, S.A. et al. (2002) Cancer Res 62, 6639-44.

研究领域
癌症,代谢,神经科学
翻译后修饰
unmodified

制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
4507

UniProt ID
Q13126

参考图片
Western blot analysis of extracts from HT29 and NIH/3T3 cells using MTAP Antibody.
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