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产品介绍
产品介绍
产品信息
克隆号
C595 (NCRC48)
Product Details
The C595 (also known as NCRC48) monoclonal antibody reacts with human mucin 1 (MUC1), a 500-1000 kDa transmembrane glycoprotein with a large mucin-like extracellular domain. The epitope of C595 is the tetrameric motif (RPAP) within the protein core of MUC1. MUC1 is highly polymorphic and is expressed on most mucosal epithelial cells, including mammary gland and some hematopoietic cells. MUC1 is heavily glycosylated and plays a crucial role in the lubrication and protection of normal epithelial cells. MUC1 is abnormally expressed in a wide variety of malignancies, including colon, breast, ovarian, lung and pancreatic cancers. MUC1 promotes cancer cell growth and metastases through multiple mechanisms. The C595 antibody has been shown to suppress ovarian tumor xenograft growth in mice.Specifications
| Isotype | Mouse IgG3, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb polyclonal mouse IgG |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Purified human MUC1 |
| Reported Applications | in vivo administration in mouse xenograft models Immunohistochemistry (paraffin) Immunofluorescence in vitro cell cytotoxicity assay Western blot |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_2894756 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
IGG-免疫球蛋白G型抗体
应用
反应种属
Human
背景
研究领域
Cancer Biology, Cell Migration & Adhesion, Tumor Antigens
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