MUC13 (E6Z1K) Rabbit mAb

Mucin proteins are glycoproteins known for providing protection and lubrication to the luminal epithelial tissues under normal physiologic conditions (1,2). There are three types of mucins based on their structure and location: transmembrane, secreted, and soluble. Mucins can function as oncogenes and exert the effect of tumor-promoting and/or tumor-suppressing factors (3). MUC13 (Mucin13) is a transmembrane mucin. The protein is expressed in the epithelium layer of large intestine, trachea, kidney, small intestine, stomach, and hematopoietic cells (4). There it regulates epithelial inflammation in response to inflammatory and infectious stimuli (5). MUC13 is aberrantly overexpressed in various cancer types including gastric (6), pancreatic (7), hepatic (8), colonic (9), renal (10), etc. The protein promotes tumorigenesis, metastasis, and induces resistance to chemotherapy via activating multiple signaling pathways, such as β-catenin signaling, Her2/EGFR signaling, and NF-kB signaling (8,9,11,12). The apparent molecular weight of MUC13 is varied from 70 to 90 kDa and 120 to 175 kDa in different cell lines, due to the different protein glycosylation status (13). 1.van Putten, J.P.M. and Strijbis, K. (2017) J Innate Immun 9, 281-299. 2.Kasprzak, A. and Adamek, A. (2019) Int J Mol Sci 20, 1288. doi: 10.3390/ijms20061288. 3.Reynolds, I.S. et al. (2019) Cancer Metastasis Rev 38, 237-257. 4.Williams, S.J. et al. (2001) J Biol Chem 276, 18327-36. 5.Sheng, Y.H. et al. (2013) Mucosal Immunol 6, 557-68. 6.Shimamura, T. et al. (2005) Cancer Sci 96, 265-73. 7.Khan, S. et al. (2017) Oncogene 36, 491-500. 8.Dai, Y. et al. (2018) Am J Pathol 188, 378-391. 9.Sheng, Y.H. et al. (2019) Oncogene 38, 7294-7310. 10.Sheng, Y. et al. (2017) Int J Cancer 140, 2351-2363. 11.Tiemin, P. et al. (2020) J Hepatol 72, 761-773. 12.Sheng, Y.H. et al. (2017) Oncogene 36, 700-713. 13.Maher, D.M. et al. (2011) Mol Cancer Res 9, 531-537.